VDR is a gene which codes for a vitamin D receptor protein. This protein regulates calcium absorption as well as bone growth. A variant of the gene, the rs2228570 (FokI polymorphism) is associated with decreased bone mineral density in white prepubescent girls.
The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is controlled by the reciprocal and temporal pattern of on- and off occupancy of the VDRE by the two components, and is modulated through chromosomal sites and binding preferences for certain hormones. Microarray studies of human cells show that more than 100 genes carry a distinct VDRE located in their promoters. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.
A virtual dataroom (VDR) can serve as a repository of information and documents relevant to legal transactions, business, or procedures. Viewing, downloading, and printing are all restricted. It is accessed via central computers and an extranet which is a restricted-access Internet connection, allowing users to login at specific times.
VDRs are typically used by investment banks and businesses involved in mergers and acquisitions. They require a secure platform to share information with investors or buyers in a manner that is transparent, and the process of due diligence can require massive amounts of data. Life science companies also utilize VDRs for everything from clinical trials results to HIPAA compliance documents.